3-羟基异丁酸脱氢酶
PDB rendering based on 2gf2.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 HIBADH; NS5ATP1
扩展标识 遗传学:608475 鼠基因:1889802 同源基因:15088 GeneCards: HIBADH Gene
EC编号 1.1.1.31
RNA表达模式
PBB GE HIBADH gnf1h05976 at tn.png
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 11112 58875
Ensembl ENSG00000106049 ENSMUSG00000029776
UniProt P31937 Q99L13
mRNA序列 NM_152740 NM_145567
蛋白序列 NP_689953 NP_663542
基因位置 Chr 7:27.57 – 27.7 Mb Chr 6:52.55 – 52.64 Mb
PubMed查询 [1] [2]
3-羟基异丁酸脱氢酶
Protein HIBADH PDB 2gf2.png
3-羟基异丁酸脱氢酶结构(PDB 2gf2)
识别码
EC编号 1.1.1.31
CAS号 9028-39-1
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本体 AmiGO / EGO

3-羟基异丁酸脱氢酶(英语:3-hydroxyisobutyrate dehydrogenaseEC 1.1.1.31)是一种以NAD+NADP+受体、作用于供体CH-OH基团上的氧化还原酶。这种催化以下酶促反应

3-羟基-2-甲基丙酸 + NAD+ 2-甲基-3-氧代丙酸 + NADH + H+

3-羟基异丁酸脱氢酶主要参与缬氨酸亮氨酸异亮氨酸降解过程。

参考文献

  • Gerhard DS, Wagner L, Feingold EA; 等. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504. 
  • Hillier LW, Fulton RS, Fulton LA; 等. The DNA sequence of human chromosome 7.. Nature. 2003, 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782. 
  • Scherer SW, Cheung J, MacDonald JR; 等. Human chromosome 7: DNA sequence and biology.. Science. 2003, 300 (5620): 767–72. PMC 2882961. PMID 12690205. doi:10.1126/science.1083423. 
  • Strausberg RL, Feingold EA, Grouse LH; 等. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Toward a complete human genome sequence.. Genome Res. 1999, 8 (11): 1097–108. PMID 9847074. doi:10.1101/gr.8.11.1097. 
  • Hughes GJ, Frutiger S, Paquet N; 等. Human liver protein map: update 1993.. Electrophoresis. 1994, 14 (11): 1216–22. PMID 8313870. doi:10.1002/elps.11501401181. 
  • Rougraff PM, Paxton R, Kuntz MJ; 等. Purification and characterization of 3-hydroxyisobutyrate dehydrogenase from rabbit liver.. J. Biol. Chem. 1988, 263 (1): 327–31. PMID 3335502. 
  • Rougraff PM, Zhang B, Kuntz MJ; 等. Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases.. J. Biol. Chem. 1989, 264 (10): 5899–903. PMID 2647728.